fig2

Figure 2. Centrosome duplication cycle. Centrosome duplication begins at the G1-S transition, with the disengagement of the pair of centrioles. Plk4 binds and phosphorylates STIL and associates with SAS-6. Thus, the cartwheel forms the proximal wall of the mother centriole. Other proteins are recruited to the cartwheel and the new daughter centriole (procentriole) begins to grow from the existing centrioles during S and reaches the full length at the G2 phase. Duplicated centrosomes separate at the beginning of the M phase, helped by kinases NEK2a and Plk1. PCM mature and the cartwheels disassemble in the early M phase. After the separation of two daughter cells, each cell inherits one centrosome. The figure is adapted and modified^[15]