fig1

Figure 1. Representative figure of the crystal structure of the EGFR kinase domain, highlighting the N- and C-terminal lobes, as well as the phosphate coordinating P-loop (blue) and activation loop (A-loop). The active site lies in the cleft between the A-loop (red) and the C-lobe. The regulatory C-helix is colored in green. Sites of activating mutations are indicated in yellow. EGFR: epidermal growth factor receptor