fig4

Figure 4. Multidrug-resistance (MDR) depends on a series of factors, including absorption, distribution, metabolism, elimination (ADME), drug influx and efflux, drug activation/inactivation, drug target alteration, DNA damage repair, cell death inhibition, epigenetic alteration and epithelial-to-mesenchymal transition (EMT). Sorcin contributions to the onset of a MD-resistant phenotype are indicated in red (see text)