fig1

Figure 1. Schematic representation of sphingosine-1-phosphate (S1P) pathway. Summary of sphingolipid degradation and synthesis and major components of the S1P metabolic pathway implicated in ovarian cancer progression and drug resistance. SMase: sphingomyelinase; CDase: ceramidase; SPHK1/2: sphingosine kinase 1/2; SPNS2: Spinster homolog 2; ABC transporter: ATP-binding cassette transporters, ABCA1, ABCC1, and ABCG1; S1PR1,2,3,4,5: S1P receptor; SMS: sphingomyelin synthase; GCS: glucosylceramide synthase; GlcCer: glucosylceramide; CERT: ceramide transport protein; SPT: serine palmitoyltransferase; CerS: ceramide synthase; SPPase: S1P Phosphatases