Hot Keywords
Drug Resistance Mechanisms Epigenetic Resistance in Cancer Therapy Biomarkers Pharmacogenetics of Cancer Liquid Biopsy Targeted Cancer Therapy Non-coding RNAs Kinase Inhibitors ABC Transporters

Topic: Targeting Signaling Pathway to Overcome Drug Resistance for Cancer Therapy

A special issue of Cancer Drug Resistance

ISSN 2578-532X (Online)

Submission deadline: 31 Mar 2022

Guest Editor(s)

  • Dr. Mario Cioce
    Faculty of Medicine and Surgery, University Campus-Biomedico, Rome, Italy.

    Website | E-mail

  • Dr. Maria Rosaria De Miglio
    Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

    Website | E-mail

Special Issue Introduction

Resistance to therapy is major challenge of the clinical management of cancer patients. Recent approaches have shown how intra-tumoral heterogeneity (ITH) is a major propeller of drug resistance, because of the clonal evolution and the consequent broad spectrum of stress- adaptive mechanisms set in place in therapy-challenged tumors. Omics approaches, including transcriptomic, genomic, proteomics and metabolomics analysis and targeted at both cancer cells and tumor microenvironment, are expected to greatly contribute knowledge of resistance mechanisms to overcome such a challenge. Another critical point is the choice of relevant sources and experimental settings to study resistance to therapy. This broadly covers in vitro cell culturing up to 3D cultures and organoids, with the last two holding more promise due to the ability to keep a more intact genetic makeup of the originating specimen. Current efforts to overcome cancer drug resistance do need to consider, on one hand, the high need for novel agents and, on the other hand, potential for drug repositioning and sequencing of treatments. This requires a tighter than ever interaction between basic, translational and clinical scientist and to this interdisciplinary audience is devoted this special issue of Cancer Drug Resistance.


Signaling pathways, Targeted therapies, Single-cell biology, Nanomedicines, Precision oncology ,Omics, Drug resistance, Cancer stem cells, Epithelial mesenchymal transition, Metabolism, Tumor Microenvironment

Submission Deadline

31 Mar 2022

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 31 Mar 2022
Contacts: Bella Zhao, Assistant Editor,

Published Articles

© 2016-2023 OAE Publishing Inc., except certain content provided by third parties