Guest Editor(s)

• Prof. Iwao Ojima

  Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.

  Website | E-mail

Special Issue Introduction

Extensive investigations into efficacious tumor-targeting drug delivery systems (TTDDS) for cancer chemotherapy based on monoclonal antibody – drug conjugates (ADCs) in the last 2 decades have resulted in 4 FDA-approved ADCs, and a large number of ADCs are currently in clinical trials. Through the development of these first-generation ADCs, focused efforts have been made on the discovery of efficacious monoclonal antibodies (mAbs) specific to particular cancers, selection of extremely potent payloads (cytototoxic anticancer drugs), and invention of "smart" linkers. Recently, the second generation of ADCs is emerging in which a less cytotoxic payload with a higher loading on mAb and a "smarter" linker are used, exploiting the bystander effects. Cite-specific loading of payloads on mAbs is also advanced to produce structurally well-defined and homogeneous ADCs rather than undefined mixture used in the first-generation ADCs. Besides ADCs, small-molecule drug conjugates (SMDCs) have been extensively studied. Although no SMDCs have been FDA approved yet, at least one SMDC advanced to the Phase III clinical trials. Thus, this approach has a promise in the future. As the tumor-targeting module, mAb's Fab fractions, tumor-specific synthetic proteins by protein-engineering and DNA/RNA-based aptamers have been showing certain promise. "Smart" linker technologies have also be advancing through chemical biology research. The second-generation ADC approach has opened up possibilities for the use of much broader range of cytotoxic payloads. Therefore, it is a very good time to summarize the recent advances in the tumor-targeting chemotherapy drugs by collecting articles from leading researchers at the 20th anniversary of the first FDA-approval of ADC, Mylotarg, in 2000, and explore future prospects in this field of pharmaceutical research.

Participants

1. Philip Low  Purdue University, West Lafayette, United States. 
2. Walter Kolch and Austin Duffy  School of Medicine, University College Dublin, Dublin, Ireland.
3. Lloyd Trotman  Cold Spring Harbor Laboratory, Cold Spring Harbor, NY United States.
4. Sanjeeb Kumar Sahoo  Nanomedicine Laboratory, Institute of Life Sciences India, Bhubaneswar, India.
5. Yoshikazu Nakamura  Division of RNA Medical Science, Institute of Medical Science, University of Tokyo, Japan.
6. Rajeswari Sundararajan  Purdue University, West Lafayette, United States.
7. Jacopo Giuliani  Mater Salutis Hospital, Legnago (Verona), Italy.
8. Dhananjay Pal  University of Missouri-Kansas City, Kansas City, United States.
9. Carmen Veríssima Ferreira Halder  Universidade Estadual de Campinas, Campinas, Brazil.
10. Elena V Batrakova  The University of North Carolina at Chapel Hill, Chapel Hill, United States.
11. Ahmet Taner  Anadolu Üniversitesi, Eskisehir, Turkey.
12. William Gmeiner Wake Forest School of Medicine, Winston Salem, United States.
13. Peters, G. J. Amsterdam UMC - Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
14. Ayşe Erdoǧan Alanya Alaaddin Keykubat University, Antalya, Turkey.
15. Neelam Sharma-Walia Chicago Medical School, Chicago, United States.
16. Gerhard Hamilton Medizinische Universitat Wien, Vienna, Austria.
17. Vladimir Torchilin Northeastern University, United States.
18. David Philip Lane Agency for Science, Technology and Research, Singapore.
19. Sarah C. Crawford Southern Connecticut State University, United States.
20. Appu Rathinavelu Nova Southeastern University, United States.
21. Sibaji Sarkar MBC College, United States.
The list is arranged in no particular order and being updated.

Submission Deadline

31 Jan 2021

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://cdrjournal.com/pages/view/author_instructions
For Online Submission, please login at https://oaemesas.com/CDR/?IssueId=497
Submission Deadline: 31 Jan 2021
Contacts: Lori Kang, Assistant Editor, lori@cdrjournal.com