- Prof. Thomas Litman
- Faculty of Health and Medical Sciences, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark.
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Special Issue Introduction
ABC transporters, such as P-glycoprotein and ABCG2, are known to confer multidrug resistance (MDR) in cancer, thus rendering previously sensitive cancer cells multi-resistant to a large range of chemically unrelated compounds.
The aim of this special issue is to sum up the latest knowledge on the role and function of ABC transporters in cancer.
Specifically, the latest development on the following topics will be reviewed:
- The mechanisms of MDR and the implications for clinical drug resistance.
- How cancer cells increase MDR1 (ABCB1) expression.
- Evidence for the importance of ABC transporters in cancer.
- Regulation of the expression and trafficking of ABCG2.
- Defeating multidrug resistance in cancer: a new twist on an old story.
KeywordsMultidrug resistance, ABC transporters, cancer, drug resistance, P-glycoprotein, ABCG2
Submission Deadline20 Nov 2020