Hot Keywords
Drug Resistance Mechanisms Epigenetic Resistance in Cancer Therapy Biomarkers Pharmacogenetics of Cancer Liquid Biopsy Targeted Cancer Therapy Non-coding RNAs Kinase Inhibitors ABC Transporters

Topic: Research Advances and New Challenges in Overcoming Triple-Negative Breast Cancer

A special issue of Cancer Drug Resistance.

ISSN 2578-532X (Online)

Submission deadline: 30 Sep 2020

Guest Editor(s)

  • Professor Masakazu Toi, M.D. Ph.D
    Kyoto University Graduate School of Medicine, Kyoto, Japan.

    Website | E-mail

Special Issue Introduction

Triple negative breast cancer (TNBC) having hormone receptor negative and HER2 negative phenotype is a disease consisting of heterogeneous populations. Biological properties differ significantly among these subpopulations, so that multiple treatment strategies and a variety of approaches would be required to overcome the disease. In common practice, chemotherapies, such as anthracyclines, microtubules inhibitors and oral fluoropyrimidines, are most frequently used. Although the survival outcomes have been improved in recent years, still many patients have got disease relapses due to drug resistance. Therefore, There is an urgent need to know more about chemotherapy resistance and to create novel therapeutics and approaches. Nowadays, more attention is paid to the immune-oncology (IO) agents especially for tumors having PD-L1+ infiltrating immune cells. It would improve overall survival (OS) for re-clisponders presumably. Many other agents and combinations are currently investigated in laboratory and tested in clinics, where not only IO aspects and gene repair disorders but also epithelial mesenchymal transition (EMT), induction of stem-like cell phenotype, androgen receptor activation, altered nuclear acid metabolism and lipid metabolism are intensively studied. Furthermore, various antibody drug conjugate researches are also going on. In this review, we would like to focus upon the frontier of new therapeutics development for TNBC disease from biological aspects and clinical aspects. New translational research aspects would be involved as well.


Breast cancer, triple negative, immuno-oncology, DNA repair, chemotherapy resistance, molecular target, epithelial mesenchymal transition, androgen receptor

Submission Deadline

30 Sep 2020

Submission Information

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Submission Deadline: 30 Sep 2020
Contacts: Chloe Yang, Assistant Editor,

Published Articles

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