- Prasad Dandawate, Ph.D
- Research Assistant Professor, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS66160, USA.
- Shrikant Anant, Ph.D
- Professor and Chair, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS66160, USA.
Special Issue Introduction
Despite major technological advances and exhaustive research on cancer cell behavior and drug development, cancer remain the major cause of deaths worldwide. Although a number of anticancer drugs have been developed in the past for the treatment, clinically they face the major problem of drug resistance and toxicity. Drug resistance may be because the cancer is intrinsically resistant to particular drugs or developed over a course of treatment. Recently, the discovery of cancer stem cells (CSCs) that can self-renew and differentiate has been proposed to play a role in drug resistance. Hence, there is a need for novel drugs that are non-toxic in nature, have ability to target multiple pathways and CSCs as well as have chemo-sensitizing properties.
Phytochemicals have been isolated from fruits (Resveratrol from Grapes), vegetables (Diindolylmethane from broccoli), spices (Curcumin from Turmeric), beverages (Epigallocatechin gallate from Green Tea) and many other sources that have been extensively studied for their multitargeted activity and CSCs-eliminating properties in several cell culture systems, in animals, and in human clinical trials. Recent reports have shown phytochemicals can be used to sensitize drug-resistant cancer and produce additive activity when used in combination with current anticancer drugs. Hence, phytochemicals are excellent avenues for future anticancer drug development, especially superior in overcoming drug resistance and saving the hurdles, time and money for new drug development.
This special issue welcomes novel research and detailed review articles addressing current understanding of the role of phytochemicals in overcoming cancer drug resistance. This special issue will also serve as a forum for discussion on promises and challenges specific to phytochemical-bases anticancer drug discovery. All the submitted articles will undergo rigorous yet constructive peer-review and will be published free of charge upon acceptance.
Submission Deadline31 Jul 2020