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Drug Resistance Mechanisms Epigenetic Resistance in Cancer Therapy Biomarkers Pharmacogenetics of Cancer Liquid Biopsy Targeted Cancer Therapy Non-coding RNAs Kinase Inhibitors ABC Transporters

Topic: The Roles of Pharmacokinetics and Pharmacogenetics in Cancer Drug Resistance

A special issue of Cancer Drug Resistance

ISSN 2578-532X (Online)

Submission deadline: 30 Sep 2022

Guest Editor(s)

  • Prof. Roger M. Phillips
    Department of Pharmacy, School of Applied Sciences, University of Huddersfield, United Kingdom.

    Website | E-mail

  • Prof. Godefridus J. (Frits) Peters

    Amsterdam UMC, location VUMC, Laboratory Medical Oncology, Cancer Center, Amsterdam, The Netherlands.

    Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland.

    Website | E-mail

Special Issue Introduction

The fate of a drug and its ability to exert a pharmacological effect is determined by many factors including its pharmacokinetic (PK) profile. Moreover, the PK of a drug can be modulated by pharmacogenetic (PG) properties, either systemic or of the tumor. Both PK and PG determine, ultimately, the concentration (C) of drug delivered to tumor cells and the duration (T) of drug exposure. Drug delivery to tumors is often impaired and PK resistance is an emerging but often overlooked issue in oncology. PK resistance effectively describes the impact that PG, biological, physiochemical, micro-environmental factors etc. have on drug delivery (C and T parameters) and is a major contributing factor to the problem of cancer drug resistance.

In this special issue we welcome papers focusing on how a drug’s PK or PG profile may lead to drug resistance. The issue is also open for papers that discuss how barriers to effective drug delivery to tumors can be overcome with the aim of identifying key challenges that need to be addressed if the impact that PK resistance on cancer therapy is to be reduced.

Submission Deadline

30 Sep 2022

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to
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Submission Deadline: 30 Sep 2022
Contacts: Susan Song, Assistant Editor,

Published Articles

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