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    Sphingolipid metabolism and drug resistance in ovarian cancer

    Kelly M. Kreitzburg , Robert C. A. M. van Waardenburg , Karina J. Yoon
    Despite progress in understanding molecular aberrations that contribute to the development and progression of ovarian cancer, virtually all patients succumb to drug resistant disease at relapse. Emerging data implicate bioactive sphingolipids and regulation of sphingolipid metabolism as components of response to chemotherapy or development of resistance. Increases in cytosolic ceramide induce apoptosis in response to therapy with multiple classes of chemotherapeutic agents. Aberrations in sphingolipid metabolism that accelerate the catabolism of ceramide or that prevent the production and... Read more
    Published on: 13 Jul 2018  | Viewed:670  | Downloaded:62
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Cancer Drug Resistance ISSN 2578-532X (Online)
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