LATEST
  • image 12 Dec 2017 Topic: How does the prostate cancer microenvironment affect the metastatic process and/or treatment outcome?| Open Access

    Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention

    Agnese C. Pippione , Donatella Boschi , Klaus Pors , Simonetta Oliaro-Bosso , Marco L. Lolli

    Androgens play an important role in prostate cancer (PCa) development and progression. Although androgen deprivation therapy remains the front-line treatment for advanced prostate cancer, patients eventually relapse with the lethal form of the disease. The prostate tumor microenvironment is...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:40 Downloaded:4
  • image 8 Dec 2017 Topic: Alzheimer’s Disease| Open Access

    Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer’s disease

    Lindsay H. Burns , Hoau-Yan Wang

    Alzheimer’s disease (AD) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (Aβ) and tau proteins. Defective amyloid and tau propagate and aggregate, leading to eventual amyloid plaques and neurofibrillary tangles. New data show that a third...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:159 Downloaded:8
  • image 31 Oct 2017 Topic: Cancer Immunotherapy| Open Access

    Cancer immunotherapy: a brief review of the history, possibilities, and challenges ahead

    Stanley J. Oiseth , Mohamed S. Aziz

    The knowledge that the body possesses natural defenses to combat cancer existed long before the modern period, with multiple anecdotal reports of tumors miraculously disappearing, sometimes spontaneously or after a febrile or infectious episode. Spontaneous tumor regression of untreated malignant...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:1801 Downloaded:896
  • image 22 Nov 2017 Original Article| Open Access

    Standardized protocol proposed for clinical use of L-PRF and the use of L-PRF Wound Box®

    Alessandro Crisci , Domenico Lombardi , Edda Serra , Guido Lombardi , Federica Cardillo , Michela Crisci

    Aim: The hypothesis is that the production of leukocyte and platelet-rich fibrin (L-PRF) is easy in horses without modifying human protocol, thus allowing better standardization of human protocol. In this study, the aim is to standardize the production of L-PRF in horses to direct it to human...

    Journal of Unexplored Medical Data [HTML] [PDF] Viewed:97 Downloaded:11
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  • image 34408 Topic: Infectious Disease of Central Nervous System| Open Access

    Current diagnosis and treatment of cryptococcal meningitis without acquired immunodeficiency syndrome

    Xiao-Su Guo , Hui Bu , Jun-Ying He , Yue-Li Zou , Yue Zhao , Yuan-Yuan Li , Jun-Zhao Cui , Ming-Ming Zheng , Wei-Xin Han , Ze-Yan Zhao

    Cryptococcal meningitis (CM) is a central nervous system infectious disease caused by Cryptococcus. It is the most common fungal infection in the central nervous system, accounting for about 48% of fungal infection. The disease occurs mainly in acquired immunodeficiency syndrome (AIDS) patients...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:34408 Downloaded:282
  • image 213343 Review| Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo

    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:213343 Downloaded:669
  • image 20874 Topic: Biomaterials for Plastic and Aesthetic Surgery| Open Access

    Intradermal fillers for minimally invasive treatment of facial aging

    Zhi Yuan (William) Lin , Vishva Shah , Arvind Dhinakar , Lara Yildirimer , Wen-Guo Cui , Xin Zhao

    The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses...

    Plastic and Aesthetic Research [HTML] [PDF] Viewed:20874 Downloaded:996
  • image 26572 Review| Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard

    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host...

    Hepatoma Research [HTML] [PDF] Viewed:26572 Downloaded:878
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